Department of Biological Science
The Florida State University
Lecture: M W F 11:15 am Spring
2005
Room: 228 Conradi Bldg.
Office: 235 Biomedical Research Facility Email:jfadool@bio.fsu.edu
Office Hours: M R 12:30-1:30;
Or by appointment.
Help Session: M, 515-615, 208
BIO
TA: Rizkallah, Raed
Phone: 850-644-4233
Office:
Email: rrizkallah@bio.fsu.edu
Required Text: Essentials
of Genetics, 5th ed.
W.S.Klug and M.R. Cummings;
Prentice Hall, 2005.
Essentials of Genetics,
Student Handbook & Solutions Manual,
H. Nickla, Prentice Hall, 2005.
This
is an exciting time to be a geneticist.
The human genome project, computer resources and computational methods
and the ever-growing methodologies for manipulating genes have propelled a
field fundamental to all areas of biology.
The objective of this course is to provide undergraduate students with
an understanding of the fundamental concepts of genetics and molecular
biology. Apart from being a required
course for majors in Biological Science and strongly recommended for others
interested in careers in medicine or allied health professions, genetics shapes
our understanding of human health and disease, evolution, agriculture,
conservation biology and yes even political affairs. The transmission of genetic material from one generation to the
next is what makes biology truly unique amongst the natural sciences. The classical experimental investigations
illustrate the development of the scientific method and the evolution of
genetics as a field of study. The
principles of human genetics, methods in molecular biology and the lessons from
cancer biology demonstrate the applications of genetics to our understanding of
health and disease in society.
The
lecture material is divided into 2 general areas, Transmission Genetics and
Molecular Genetics. The reading assignments
are intended to prepare the students for the lectures. When reading, you should focus on the goals
as outlined in the text and familiarize yourself with the terminology. More so than many areas of biology,
analytical skills and problem solving are fundamental to an understanding of
transmission genetics. The recommended
problems in the back of each chapter highlight the important points of study
and the applications of the lecture material.
The solutions to several questions will be reviewed in the help session
held each week. Although attendance is
not compulsory, it is strongly encouraged.
Grade Policy: There
will be three one-hour exams, each worth 20% of the final grade, and a final
exam, worth 40% of the final grade. The
hour exams will emphasize material covered in that quarter of the course, but
students are responsible for all course material presented to that date. The final exam will be cumulative with a
section devoted to the latest class material and others that specifically
address topics from the first 3 sections of the course.
Quizzes covering the reading
material, lecture material, or recommended problems will be given at the
beginning of class on a regular but unannounced basis. The most obvious goal is to encourage each
student to come to class prepared for lecture and having reviewed previous
material. Genetics covers a broad range
of principles from inheritance and probability to molecular biology and its
applications. Preparation is
essential. A second goal is to provide
students with samples of the types of questions and depth of understanding to
be expected on the Exams. There are no
“Old Exams.” The average on the quizzes
count as bonus point and will be factored into the hourly exam score for that
section of the course. There will be no make-up quizzes as these will be graded
immediately following administration.
There will be no extra credit, so take advantage of the opportunity
offered by the quizzes to improve your grade.
There is no rounding-up of averages.
Grade Scale:
A 93-100 C+ 77-79
A- 90-92 C 70-78
B+ 87-89 C- 66-69
B 83-86 D 60-65
B- 80-82 F Below 60
Students with disabilities needing academic accommodation should; (1) register with and provide documentation to the Student Disability Resource Center; (2) bring a letter to the instructor indicating the need for accommodation and what type. This should be done during the first week of class.
Attendance at lectures should not be viewed as unnecessary. There is no substitute for the interaction between the instructor and students. Questions during lecture are actively encouraged. Furthermore, supplemental information, not present in the text, may be provided. Likewise, it is expected that students will study the assigned material in the text as all requisite information cannot be presented in lecture.
Attendance at Lecture Exams is required. Absences will only be condoned if an Acceptable and Verifiable excuse is provided as outlined in the Student Handbook. Students are expected to uphold the Academic Honor Code. Failure to take an examination at the designated time will result in a ZERO (0) score. The Academic Honor System of The Florida State University is based on the premise that each student has the responsibility (1) to uphold the highest standards of academic integrity in the student's own work, (2) to refuse to tolerate violations of academic integrity in the university community, and (3) to foster a high sense of integrity and social responsibility on the part of the university community.
Proposed Course
Schedule
Lecture Date Topic Chapter
WEEK 1
1 Jan 5 Introduction;
History of Genetics 1: 2,4,6
2 7 Cell
Cycle Review 2: 1-5,8,12,13,15,17
WEEK 2
3 10 Mendelian
Principles 3: 1,2,5,6,7,8,11,13,14,16,24
4 12 Mendelian
Principles 3
5 14
Probability & Human Pedigrees 3
WEEK 3
6 17 MARTIN LUTHER KING Jr. HOLIDAY
7 19 Modifications of Mendelian Ratios 4
8 21 X-Linkage 4
WEEK 4
9 24 Additional
Gene Interactions 4
10 26 Sex Differentiation 5
11 28 Imprinting
& Dosage Compensation 4 & 5
WEEK 5
12 31 Quantitative Genetics 6
13 Feb
2 Complete & Review Section 1
14 4 **** LECTURE EXAM 1 ******
WEEK 6
15 7 Cytogenetics 7
16 9 Chromosome
Variation 1 7
17 11
Chromosome Variation 2 7
WEEK 7
18 14
Linkage in Eukaryotes 8
19 16
Linkage in Eukaryotes 8
20 18
Population Genetics 22
WEEK 8
21 21 Population Genetics 22
22 23 DNA as Heredity Material 10
23 25 Chemical Structure of Nucleic Acids 10
WEEK 9
24 28
Complete & Review Section 2
25 Mar 2
****
LECTURE EXAM 2 ******
26 4 DNA Replication 11
WEEK 10
SPRING
BREAK
WEEK 11
27 14 DNA Replication 11
28 16 DNA Structure and Organization 12
29 18 Transcription
13
WEEK 12
30 21 Introns-Processing 13
31 23 Translation 14
32 25
Translation and Proteins 14
WEEK 13
33 28 Hemoglobin & Sickle Cell Anemia pp 307-309
34 30 Regulation of Eukaryote Transcription 16
35 Apr 1 Review 12
WEEK 14
36 4 ****
LECTURE EXAM 3 ******
37
6 Library
Resources TBA
38
8 Mutations 15
39
WEEK 15
39 11
Developmental Genetics 20
40 13 Developmental
Genetics 2 TBA
41 15 Cancer
Genetics 21
WEEK 16
42 18 Molecular Techniques 17
43 20 Student Selected Topic
44 22 Review
WEEK 17
April 28 *******FINAL
EXAM*******
*******12:30-2:30pm*******