Department of Biological Science

Biological Science Faculty Member

Associate Professor
Ph.D., University of Houston, 2000
Graduate Faculty Status

We are interested in the molecular and cellular mechanisms through which sleep and the circadian clock affect neural plasticity from drug tolerance to long-term memory. We use Drosophila melanogaster and mice for our research with sleep deprivation.

Research and Professional Interests:

Mechanisms through which the circadian clock and sleep modulate neural plasticity and memory formation

Selected Publications:

 DeNobrega, A.K., Noakes, E.J., Storch, N.A, Mellers, A.P. & Lyons, L.C. (2021 BioRxiv). Sleep modulates alcohol toxicity in Drosophila. In revision for Sleep

Gaine, M.E., Bahl, E., Chatterjee, S., Michaelson, J., Abel, T. and L.C. Lyons (2021 ) Altered hippocampal transcriptome dynamics following sleep deprivation. In revision for Molecular Brain. Aug 12;14(1):125. doi: 10.1186/s13041-021-00835-1.

Parnell, A. A., De Nobrega, A. K., & Lyons, L. C. (2020). Translating around the clock: Multilevel
regulation of post-transcriptional processes by the circadian clock. Cellular
Signaling. doi:doi: 10.1016/j.cellsig.2020.109904

Lyons, L. C., Chatterjee, S., Vanrobaeys, Y., Gaine, M., & Abel, T. (2020). Translational
changes induced by acute sleep deprivation uncovered by TRAP-Seq. Molecular Brain.
doi:doi: 10.1186/s13041-020-00702-5

Chatterjee, S., Angelakos, C., Bahl, E., Hawk, J., Gaine ME, Poplawski, S., Schneider-Anthony, A., Yadav, M., Porcari, G., Cassel, J., Giese, K., Michelson, J., Lyons, L. C., Boutilier,
Anne-Laurence, & Abel, T. (2020). The CBP KIX domain regulates long-term memory
and circadian activity. BMC Biology, 18(1), 155. doi:doi: 10.1186/s12915-020-00886-1

De Nobrega, A. K., & Lyons, L. C. (2018). Aging and the Clock: Perspective from Flies to
Humans. European Journal of Neuroscience. doi:doi: 10.1111/ejn.14176.

De Nobrega, A. K., Mellers, A. P., & Lyons, L. C. (2017). Aging and circadian dysfunction
increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.
Experimental Gerontology, 97, 49-59.

De Nobrega, A. K., & Lyons, L. C. (2017). Drosophila: An Emergent Model for Delineating
Interactions between the Circadian Clock and Drugs of Abuse. Neural Plasticity,
2017,Article ID 4723, 28. doi:10.1155/2017/4723836

Krishnan, H., Gandour, C., Ramos, J., Wrinkle, M., Sanchez-Pacheco, J., & Lyons, L. (2016). Acute Sleep Deprivation Blocks Short and Long-Term Operant Memory in Aplysia. Sleep, 39 (12), 12.

Lyons, L., Gardner, J., Gandour, C., & Krishnan, H. (2016). Role of proteasome dependent protein degradation in long-term operant memory in Aplysia. Learning and Memory, 15(24), 59-64. 
 
Lyons, L., Gardner, J., Lentsch, C., Gandour, C., Krishnan, H., & Noakes, E. (2016). Differential role of calpain-dependent protein cleavage in intermediate and long-term operant memory in Aplysia. Neurobiology of Learning and Memory, 137, 134-141. 
 
Krishnan, H., Noakes, E., & Lyons, L. (2016). Chronic Sleep Deprivation Differentially Affects Short and Long-term Operant Memory in Aplysia. Neurobiology of Learning and Memory, 134B, 349-359.
De Nobrega, A. K., & Lyons, L. (2016).

Circadian Modulation of Alcohol-Induced Sedation and Recovery in Male and Female Drosophila. Journal of Biological Rhythms, 31(2), 142-160. doi:10.1177/0748730415627067.
 
Krishnan, H.C. and Lyons, L.C. (2015) Synchrony and desynchrony in circadian clocks: impacts on learning and memory. Learning and Memory. 22(9):426-437.

Vorster, Albrecht P. A.; Krishnan, Harini C.; BSc; Cirelli, Chiara; MD, PhD; Lyons, Lisa C. 2014. Characterization of sleep in Aplysia californica. Sleep. 37 (9):1453-1463.

Michel, M. and Lyons, L.C. 2014. Unraveling the complexities of circadian and sleep interactions with memory formation through invertebrate research. Frontiers in Systems Neuroscience. 8:133. doi: 10.3389/fnsys.2014.00133

van der Linde K, Fumagalli E, Roman G, Lyons LC. 2014. The FlyBar: Administering Alcohol to Flies. Journal of Visualized Experiments May 18; (87).

Michel M, Gardner JS, Green CL, Organ CL, Lyons LC. 2013. Protein phosphatase-dependent circadian regulation of intermediate-term associative memory. Journal of Neuroscience 33(10): 4605-13.

Winbush A, Reed D, Chang PL, Nuzhdin SV, Lyons LC, Arbeitman MN. 2012. Identification of gene expression changes associated with long-term memory of courtship rejection in Drosophila males. G3 2(11):1437-45.

Michel, M., C. L. Green, J. S. Gardner, C. L. Organ, and L. C. Lyons. 2012. Massed training induced intermediate term operant memory in Aplysia requires protein synthesis and multiple persistent kinase cascades. Journal of Neuroscience. 32(13):4581-91.

Lyons L. C. 2011. Critical role of the circadian clock in memory formation: lessons from Aplysia. Frontiers in Molecular Neuroscience 4:52.

Michel, M., C. L. Green, A. Eskin, and L. C. Lyons. 2011. PKG-mediated MAPK signaling is necessary for long-term operant memory in Aplysia. Learning and Memory 18:108-117.

van der Linde, K., and L. C. Lyons. 2011. Circadian modulation of acute alcohol sensitivity but not acute tolerance in Drosophila. Chronobiology International 28:397-406.

Levitan, D., R. Twitto, R. Levy, L. C. Lyons, and A. J. Susswein. 2010. A brief retraining regulates the persistence and lability of a long-term memory. Learning and Memory 17:402-406.

Michel, M., C. L. Green, and L. C. Lyons. 2010. PKA and PKC are required for long-term but not short-term in vivo operant memory in Aplysia. Learning and Memory 18:19-23.

Lyons, L. C., and G. Roman. 2009. Circadian modulation of short-term memory in Drosophila. Learning and Memory 16:19-27

Gerstner, J. R., L. C. Lyons, K. P. Wright, Jr., D. H. Loh, O. Rawashdeh, K. L. Eckel-Mahan, and G. W. Roman. 2009. Cycling behavior and memory formation. Journal of Neuroscience 29:12824-12830.

 

Graduate Students:

Storch, Natalie