FSU Biology - Directories - Faculty

Biological Science Faculty Member

Dr. James Jordan

Dr. James Jordan


Assistant Professor, Ph.D., Duke University, 2021
Graduate Faculty Status

Epigenetic regulation of metabolism in health and disease.


Research and Professional Interests:

Metabolic enzymes are essential for life but promote disease and aging when expressed inappropriately. Where, when, and how much of a metabolic enzyme is expressed is determined by the complex interplay of gene regulatory networks. Although numerous (patho)physiological circumstances are affected by metabolic enzyme regulatory networks, the inter- and intracellular mechanisms controlling them are still not fully elucidated. We will address these fundamental unsolved problems in cell biology, focusing on the epigenetic regulatory mechanisms of hepatic gene expression. This regulation has critical implications for human health, and its dysregulation is associated with many diseases, including cardiovascular disease, fatty liver disease, and diabetes. In particular, deciphering the influence of the environment on hepatic gene expression will broaden our knowledge of metabolic pathology and enable us to identify new therapeutic targets.

Major projects in the lab will focus on the following questions:

  • How do dietary inputs signal to regulators to drive transcriptional programs?
  • How do dietary inputs cause cellular reprogramming across temporal and spatial scales?
  • Can we manipulate metabolic gene regulatory networks to increase healthspan?

We employ multidisciplinary approaches encompassing microscopy, biochemistry, and multiomic-based analytics to resolve these longstanding mysteries in the fields of gene expression and metabolism.

Selected Publications:

1. Jordan, JM, Qiao, J, Zou, C, Stenseels, S, Haczeyni, F, Fraim, A, Mendoza, A, de Jong, YP, and Ersoy, BA. (2024). Ybx1 guides C/EBPα and cBAF chromatin-remodeling complex to promote adipogenic gene expression in steatotic hepatocytes. bioRxiv. doi: https://doi.org/10.1101/2024.10.25.620017. (Preprint)

 

2. Haczeyni, F, Steensels, S, Stein, BD, Jordan, JM, Li, L, Dartigue, V, Sarklioglu, SS, Qiao, J, Zhou, X, Dannenberg, AJ, Iyengar, NM, Yu, H, Cantley, LC, and Ersoy, BA. (2023). Submitochondrial protein translocation upon stress inhibits thermogenic energy expenditure. bioRxiv. (Preprint)

 

3. Jordan, JM, Webster, AK, Chen, J, Chitrakar, R, and Baugh, LR. (2023). Early-life starvation alters lipid metabolism in adults to cause developmental pathology in Caenorhabditis elegans. Genetics, 223(2). PMC9910403.

 

4. Shaul, N, Jordan, JM, Falsztyn, I, and Baugh, LR. (2023). Insulin/IGF-dependent Wnt signaling promotes formation of germline tumors and other developmental abnormalities following early-life starvation in Caenorhabditis elegans. Genetics, 223(2), iyac173. PMC9910406.

 

5. Jordan, JM, Hibshman, JD, Webster, AK, Kaplan, RE, Leinroth, A, Guzman, R, Maxwell, CS, Chitrakar, R, Bowman, EA, Fry, AL, Hubbard, EJA, and Baugh, LR. (2019). Insulin/IGF signaling and vitellogenin provisioning mediate intergenerational adaptation to nutrient stress. Current Biology, 29(14), 2380-2388. PMC6650306.

 

Complete List of Published Work can be found in MyBibliography.