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Date:
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Lecture#
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Topic:
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Text:
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26 Aug T |
1 KIN1056 |
Introduction Basic Electricity |
Hille Chapter 1; Primary Literature |
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Course Overview; Selection of Assignments definitions and calculations for electricity |
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30 Aug F |
2 BIO367 |
Electrical Circuits |
Gerrish et al. Chapters 1 & 6 |
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definitions and calculations for circuits |
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3 Sept T |
3 KIN1056 |
Measuring Biological and Optical Signals |
Aidley Chapters 1-3 |
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amplifiers and voltage-clamp circuits, definitions of optical probes and equipment |
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6 Sept F |
4 BIO367 |
Ion Movement in Excitable Cells |
Hille Chapter 2 |
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Nernst potential;
Goldman-Hodgkin-Katz, physical laws that dictate ion movement |
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10 Sept T |
5 KIN1056 |
Electrical Properties of the Excitable Membrane |
Hille Chapter 3 |
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biological circuits,
membrane conductance, parallel conductance model, IV relationships |
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12
Sept Th PM |
6 KIN3009 |
Electrical
Properties of the Excitable Membrane |
Hille Chapter 3 |
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parallel
conductance model, IV relationships |
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13 Sept F |
7 BIO367 |
Channel Presentation #1 Discussion Leader: Rimil Goy Roy |
Primary Literature; Hille Chapter 5 |
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Potassium Channels |
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24 Sept T |
8 BIO367 |
Functional Properties of Dendrites
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Primary Literature |
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electrotonic properties, nonisopotential cells (cylinders), rall model for neurons |
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26
Sept Th PM |
9 HURRICANE HERMINE NO CLASS |
Nonlinear Properties of Excitable
Membranes |
Hille Chapter 2 |
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membrane rectification, Hodgkin & Huxley gate
model, constant field model |
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27 Sept F |
10 HURRICANE HERMINE NO CLASS |
Channel Presentation #2 Discussion Leader: Paria Salemi |
Primary Literature; Hille Chapter 6,7 |
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Transmitter or Ligand-gated Channels |
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1 Oct T |
11 BIO367 |
Squid Giant Axon |
Hille Chapter 2 |
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classical voltage-clamp, H & H model, propagating
& nonpropagating AP, gating currents |
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3 Oct Th PM |
10 KIN3009 |
Channel
Presentation #2 Discussion Leader: Paria Salemi |
Primary Literature; Hille Chapter 6,7 |
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Transmitter or Ligand-gated
Channels (Hurricane
Helene Makeup Lecture) |
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4 Oct F |
12 BIO367 |
Channel Presentation #3 Discussion Leaders: Saptarsi Mitra |
Primary Literature; Hille Chapter 3 |
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Sodium Ion Channels |
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8 Oct T |
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Society for
Neuroscience |
No Class |
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11 Oct F |
13 BIO367 |
Channel
Presentation #4 Discussion Leader: Dan Gaines |
Primary Literature; Hille Chapter 4, 9 |
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Calcium Channels |
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15 Oct T |
14 BIO367 |
Channel
Presentation #5 Discussion Leader: Bridger Menlove |
Primary Literature; Hille Chapter 5 |
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Chloride on Channels |
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17
Oct Th PM |
9 KIN3009 |
Nonlinear Properties of Excitable
Membranes (Hurricane Helene Makeup Lecture) |
Hille Chapter 2 |
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membrane rectification, Hodgkin & Huxley gate
model, constant field model |
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18 Oct F |
15 BIO367 |
Channel
Presentation #6 Discussion Leaders: Marty Compagno |
Primary Literature; Hille Chapter 8 |
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Second Messenger-gated /
Mechanical Ion Channels |
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22 Oct T |
16 BIO367 |
Biophysical Methods Presentation #1 Discussion Leader: Debi Fadool |
Primary Literature |
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Patch-clamp Electrophysiology |
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25 Oct F |
17 BIO367 |
Molecular Structure and
Unitary Currents of Ion Channels |
Hille Chapter 13, Sakmann/Neher Chapter 3,18, and 19 |
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molecular structure,
patch-clamp records of single-channel currents |
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29 Oct T |
18 BIO367 |
Stochastic Analysis of Single-Channel Function I |
Sakmann/Neher Chapter 18 and 19 |
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statistical analysis of single channel records, probability density functions, Markov processes, kinetic schemes, channel agonists & antagonists
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1 Nov F |
19 BIO367 |
Biophysical Methods Presentation #2 Discussion
Leader: Paria Selema |
Primary Literature |
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Multi-Electrode Arrays |
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5 Nov T |
20 BIO367 |
Stochastic Analysis of Single-Channel Function II |
Sakmann/Neher
Chapter 18 and 19 |
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statistical analysis of single channel records,
probability density functions, Markov processes, kinetic schemes, channel
agonists & antagonists |
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7
Nov Th PM |
21 KIN3009 |
Synaptic
Transmission: Presynaptic Mechanisms |
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chemical transmission, quantum hypothesis,
use-dependent synaptic plasticities |
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8
Nov F All
Day! |
Special Lectures |
Wakulla
Springs, Chemosensory Retreat |
Optional |
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14
Nov Th PM |
22 KIN3009 |
Biophysical
Methods Presentation #3 Discussion Leader: Saptarsi Mitra and Daniel Gaines |
Primary Literature |
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In Vivo Electrophysiology and Viral Infection Strategies |
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15 Nov F |
23 BIO367 |
Biophysical Methods Presentation #4 Discussion Leader: Marty Compagno |
Primary Literature
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Genetically-engineered Voltage Sensors (GEVs) |
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19 Nov T |
24 BIO367 |
Synaptic Transmission: Calcium and Transmitter Release |
pp. 323-356 |
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Calcium hypothesis, molecular mechanisms of release, and calcium domains |
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22 Nov F |
25 BIO367 |
Biophysical Methods Presentation #5 Discussion Leaders: Rimil Goy Roy |
Primary Literature |
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NMR |
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26 Nov T |
26 BIO367 |
Extracellular Field Recordings, Cellular
Neurophysiology of |
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potentials in a volume conductor, classification of fields, current source-density analysis |
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29 Nov F |
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Thanksgiving
Holidays |
No
Classes |
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3 Dec T |
27 BIO367 |
Synaptic Transmission: Postsynaptic Mechanisms & Learning/Memory |
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synaptic conductances and reversal potentials, diversity of neurotransmitters, electrical synapses, dendritic spines |
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spine shape and synaptic plasticity, Hebb rule, cellular mechanisms of LTP & LTD, correlation matrix |
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3 Dec F |
28 BIO367 |
Biophysical Methods Presentation #6 Discussion Leader: Bridger Menlove |
Primary Literature |
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Optogenetics |
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10 Dec T |
BIO367 |
Final
Examination (Week of 10 – 14 Dec) 8:00 am to
11:00 am |
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